The Prospective Instruments MPX-series is a turnkey compact multimodal microscope enabling advanced multiphoton imaging without requiring a laboratory or optical bench. One of the key design features is the ultrafast fiber laser engine integrated into the free moving scan head, which is lightweight, rugged, and allows the ultimate imaging flexibility. A modular design concept allows the user to explore a wide variety of biological applications and measurements, without compromising performance, in any indoor working space. In contrast, standard setups are non-transportable, utility-demanding, and the complexity can be complicated, therefore degrading the value and adding significant initial, short- and long-term expenses. Every clinical and biological researcher should have access to high-quality reliable optical microscopy modalities without being hardware experts. In this article we outline the demand and design of the MPX-microscope and present multiphoton imaging results from experiments in various configurations. There are no existing instruments on the market that are portable and combine easily switchable modes in one composite industry-ready device for life science, clinical, and pharmacological research.